乐游棋牌官方网址

加入收藏 | English

赵子建 教授

作者: 时间:2019-01-10


赵子建,教授,博士导师,广东工业大学百人计划特聘教授,国家特聘专家,科技部“973”重大研究计划首席科学家,江苏省特聘教授第一批人选,广东省珠江人才计划创新创业团队带头人。于美国南加州大学获得生物化学及分子生物学博士学位后在美国华盛顿州大学西雅图医学院药理学系从事药物开发研究。2000年任职匹兹堡大学医学院细胞生物和生理学系tenure-track教授直至终身教授(tenured)。赵博士的研究项目多年来得到中国科技部、自然基金委、美国NIH、美国糖尿病协会,美国心脏协会等机构支持,其成果多次以第一和通讯作者发表在Nature-Medicine Nature-Neuroscience, PNAS,JCI,Diabetes等顶尖和权威专业期刊上。曾获得美国糖尿病协会前途发展奖和研究奖。多年来注重研究成果的临床应用转化,其中一些成果已申报和获得国际专利保护,有的已经正在申报进入临床试验。


研究领域

1. 基因工程改造的微生物在肿瘤治疗中的应用;

2. 多不饱和脂肪酸代谢对糖尿病和肥胖的影响机制及药物研发;

3. 脱细胞异种生物材料在临床中的应用;

4. 肿瘤分子病理和个性化病理诊断以及代谢性相关妇科疾病研究;

5. 不孕不育的分子机理和防治。

 

主要论文

1. Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, Dai Y, Li X, Zhao AZ*. (2017) ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017 May 1;127(5):1757-1771.

2. Cheng, Lixian,Shi, Hui,Jin, Yan,Li, Xiaoxi,Pan, Jinshun,Lai, Yimei,Lin, Yan,Jin, Ya,Roy, Gaurab,Zhao, Allan*,Li, Fanghong*. (2016) Adiponect in Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in  Mice.,Endocrinology,157(12):4875~4887.

3. Li, Jie,Wei, Dong,McCrory, Mark A,Szalai, Alexander J,Yang, Gangyi,Li, Ling,Li, Fanghong(*),Zhao, Allan Z *. (2016) Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS.,Biochem J,473(9): 1215~1224.

4. Zhou S, Zhao Z, Lin Y, Gong S, Li F, Pan J, Li X, Gao Z, Zhao AZ*. (2016) Suppression of pancreatic ductal adenocarcinoma growth by intratumoral delivery of attenuated Salmonella typhimurium using a dual fluorescent live tracking system. Cancer Biol Ther, 17(7):732-40.

5. Pan J, Cheng L, Bi X, Zhang X, Liu S, Bai X, Li F, Zhao AZ*. (2015) Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production. Sci Rep. 5:14958.

6. Wei, D., Li, J., Shen, MD, Jia,W, Tian,H., Dai,Y., and Zhao, AZ *. (2010) Cellular Production of n-3 PUFAs and Reduciton of n-6/n-3 ratios in the Pancreatic b-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death. Diabetes. 59: 471-478.

7. Cong L, Gasser J, Zhao J, Yang B, Li F, Zhao AZ *.(2007) Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95- Endocr Relat Cancer. 14(3): 713-20.

8. Cong L, Chen K, Li J, Gao P, Li Q, Mi S, Wu X, Zhao AZ *. (2007) Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.  Biochem  J. 403(3): 519-25.

9. Chen, K., Li, FH, Li, J., Cai, H., Strom, S., Bisello, A., Friedman-Einat, M., Kelley, DE, McCroy, M., Szalai, A., Zhao, AZ *. (2006) Induction of Leptin Resistance through Direct Interaction ofC-Reactive Protein with Leptin. Nature Medicine 12: 425-432.

10.Li, J, Li, F, and Zhao, AZ *. (2006) Inflammation and Leptin,Drug Discovery Today: Disease Mechanisms 3 (3): 387-393.

11.Huan, J.N., Li, J., Han, Y.P., Chen, K., Wu, N., and Zhao, A.Z*. (2003) Adipocyte-Selective Reduction of the Leptin Receptors Induced by Antisense-RNA Leads to Increased Adiposity, Dyslipidemia and Insulin Resistance. J. Biol. Chem. 278: 45638-45650.

12.Zhao, A.Z., Huan, J.N. and Sahu, A. (2002) Requirement of a PI3K-PDE3B-cAMP Pathway for the   Satiety Function of Leptin in the Hypothalamus. Nature Neuroscience 5:727-728.

13.Zhao, A.Z., Shinohara, M., Huang, D., Eldar-Finkelman, H., Krebs, E.G., Beavo, J.A. and  Bornfeldt, K.E. (2000) Leptin Antagonizes the Action of Glucagon by Activating Phosphodiesterase 3B in Primary Hepatocytes.  J. Biol. Chem. 275:11348-11354.

14.Zhao, A.Z., Bornfeldt, K.E., and Beavo, JA. (1998) Leptin Inhibition of Insulin Secretion through Activation of Phosphodiesterase 3B.J. Clinc. Inves. 102: 869-873.

15.Zhao, A.Z., Zhao, H., Teague, J., Fujimoto, W., and Beavo, J.A. (1997) Attenuation of Insulin Secretion by Insulin-like Growth Factor 1 Is Mediated through Activation of Phosphodiesterase 3B.  Proc. Natl. Acad. U.S.A. 94: 3223-3228.


 

 

Copyright© 2020 乐游棋牌官方网址版权所有